本学術領域研究の研究の成果を論文発表される際には、以下の要領で必ず謝辞 をつけて頂きますようお願い致します。
(本領域の英語略称名は Memory dynamism です。)

This work was supported by the Grant-in-Aid for Scientific Research on Innovative Areas "Memory dynamism" (8桁の各自の課題番号) from the Ministry of Education, Culture, Sports, Science and Technology



Two parallel pathways assign opposing odor valences during Drosophila memory formation

東京大学・分子細胞生物学研究所 多羽田哲也 (平成30年2月27日発表)

Fast Ca2+ buffer-dependent reliable but plastic transmission at small CNS synapses revealed by direct bouton recording.

京都大学 産官学連携本部 川口真也 (平成29年12月19日発表)

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

理化学研究所・脳科学総合研究センター Joshua Johansen (平成29年9月18日発表)

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor.

生理学研究所・脳機能計測・支援センター 村越秀治 (平成29年4月5日発表)



Age-related changes in insulin-like signaling lead to intermediate-term memory impairment in  Drosophila.

千葉大学大学院薬学研究院 殿城亜矢子 (平成29年2月14日発表)

Overlapping memory trace indispensable for linking, but not recalling, individual memories.

富山大学大学院・医学薬学研究部(医学)井ノ口 馨 (平成29年1月27日発表)

Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies.

東京都医学総合研究所 学習記憶プロジェクト 齊藤実 (平成29年1月24日発表)

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

京都大学・メディカルイノベーションセンター 平野恭敬 (平成28年11月14日発表)

Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.

理化学研究所・脳科学総合研究センター 吉原 良浩 (平成28年5月30日発表)



Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection

東北大学・生命科学研究科 細川貴之 (平成28年3月9日発表)

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.

筑波大学・国際統合睡眠医科学研究機構 林悠 (平成27年10月22日発表)



Glial dysfunction causes age-related memory impairment in Drosophila.

東京都医学総合研究所・運動感覚システム研究分野  齊藤実 (平成26年11月19日発表)

Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory.

東京大学・大学院医学系研究科  尾藤晴彦 (平成26年10月1日発表)

Light and pheromone-sensing neuron regulates cold habituation through insulin signaling in C. elegans

甲南大学・理工学部/ 統合ニューロバイオロジー研究所 久原篤 (平成26年7月22日発表)


東京大学・大学院理学系研究科 飯野雄一 (平成26年7月18日発表)

Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling

理化学研究所・脳科学総合研究センター 吉原良浩 (平成26年4月9日発表)


太字下線:研究代表者、下線:研究分担者または連携研究者、*印:corresponding author


Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory. Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, *Inokuchi K.
Cell Rep. 2015;11(2):261-9.
Does autophagy work in synaptic plasticity and memory? Shehata M, *Inokuchi K.
Rev Neurosci. 2014;25(4):543-57.
Role of adult neurogenesis in hippocampal-cortical memory consolidation. Kitamura T, *Inokuchi K.
Mol Brain. 2014;7:13.
Irreplaceability of neuronal ensembles after memory allocation. *Matsuo N.
Cell Reports 2015: S2211-1247(15)00321-6.
Research and development of Ultra High Field MRI. *Hisatsune T.
Magnetics Jpn. 2014. 9: 180-186.
β-Alanyl-L-Histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer’s Disease. Herculano BA, Tamura M, Ohba A, Shimatani M, Kutsuna N, *Hisatsune T.
Journal of Alzheimer’s Disease 2013. 33, 983–997.
Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cell after focal cerebral ischemia in mice. Nochi R, Kaneko J, Okada N, Terazono Y, Matani A, *Hisatsune T.
Journal of Neuroscience Research 2013. 91, 1429-1439.
Contactin-4 Mediates Axon-Target Specificity and Functional Development of the Accessory Optic System. Osterhout JA, Stafford BK, Nguyen PL, Yoshihara Y, *Huberman AD.
Neuron. 2015;86(4):985-999.
The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Amo R, Fredes F, Kinoshita M, Aoki R, Aizawa H, Agetsuma M, Aoki T, Shiraki T, Kakinuma H, Matsuda M, Yamazaki M, Takahoko M, Tsuboi T, Higashijima S, Miyasaka N, Koide T, Yabuki Y, Yoshihara Y, Fukai T, *Okamoto H.
Neuron. 2014;84(5):1034-48.
Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling. * Miyasaka N, Arganda-Carreras I, Wakisaka N, Masuda M, Sümbül U, Seung HS, *Yoshihara Y.
Nat Commun. 2014;5:3639.
Goofy coordinates the acuity of olfactory signaling. Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, *Yoshihara Y.
J Neurosci. 2013;33(32):12987-96, 12996a.
齊藤 実
Long-term memory formation in Drosophila requires training-dependent glial transcription. Matsuno M, Horiuchi J, Yuasa Y, Ofusa K, Miyashita T, Masuda T, *Saitoe M.
J Neurosci. 2015;35(14):5557-65.
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi, Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M. (2014).
Neuron. 2014;84(4):753-63.
Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction. Kamimura K, Ueno K, Nakagawa J, Hamada R, Saitoe M, *Maeda N.
J Cell Biol. 2013;200(2):219-33.
Fasting Launches CRTC to Facilitate Long-term Memory Formation in Drosophila. *Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J, *Saitoe M.
Science 2013;339(6118):443-6.
Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston’s organ of the fruit fly. *Matsuo E, Yamada D, Ishikawa Y, Asai T, Ishimoto H, *Kamikouchi A.
Frontiers in Physiology 2014;5:179.
Selectivity and plasticity in a sound-evoked male-male interaction in Drosophila. Yoon J, Matsuo E, Yamada D, Mizuno H, Morimoto T, Miyakawa H, Kinoshita S, Ishimoto H, *Kamikouchi A.
PLOS ONE 2013. 8, e74289.
Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila. Hiroi M, Ohkura M, Nakai J, Masuda N, Hashimoto K, Inoue K, Fiala A,*Tabata T.
Genes Cells. 2013;18(12):1070-81.
The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway. Abe T, Yamazaki D, Murakami S, Hiroi M, Nitta Y, Maeyama Y, *Tabata T.
Development. 2014;141(24):4716-28.
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M.
Neuron. 2014;84(4):753-63.
石原 健
Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans. Dillon J, Franks CJ, Murray C, Edwards RJ, Calahorro F, Ishihara T, Katsura I, Holden-Dye L, *O'Connor V.
J Biol Chem. 2015. pii: jbc.M114.606608. [Epub ahead of print]
Automated detection and tracking of many cells by using 4D live-cell imaging data. Tokunaga T, Hirose O, Kawaguchi S, Toyoshima Y, Teramoto T, Ikebata H, Kuge S, Ishihara T, Iino Y, *Yoshida R.
Bioinformatics. 2014;30(12):i43-51.
Kato HE, Inoue K, Abe-Yoshizumi R, Kato Y, Ono H, Konno M, Hososhima S, Ishizuka T, Hoque MR, Kunitomo H, Ito J, Yoshizawa S, Yamashita K, Takemoto M, Nishizawa T, Taniguchi R, Kogure K, Maturana AD, Iino Y, Yawo H, Ishitani R, Kandori H, *Nureki O. Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump.
Nature. 2015;521(7550):48-53.
Regulation of experience-dependent bidirectional chemotaxis by a neural circuit switch in Caenorhabditis elegans. Satoh Y, Sato H, Kunitomo H, Fei X, Hashimoto K, *Iino Y.
J Neurosci. 2014;34(47):15631-7.
Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans. Ohno H, Kato S, Naito Y, Kunitomo H, *Tomioka M, *Iino Y.
Science. 2014;345(6194):313-7.
Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans. Kunitomo H, Sato H, Iwata R, Satoh Y, Ohno H, Yamada K, *Iino Y.
Nat Commun. 2013;4:2210.


Inhibiting the activity of CA1 hippocampal neurons prevents the recall of contextual fear memory in inducible ArchT transgenic mice. *Sakaguchi M, Kim K, Yu LMY, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ, *Hayashi Y,
PloS One, 2015, in press
Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, *Frankland PW.
J Neurosci. 2014;34(47):15793-803.
林 悠
Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. Arakawa H, Suzuki A, Zhao S, Tsytsarev V, Lo FS, Hayashi Y, Itohara S, Iwasato T, *Erzurumlu RS.
J Neurosci. 2014;34(36):12001-14.
Reward-timing-dependent bidirectional modu- lation of cortical microcircuits during optical single neuron operant conditioning. Hira R, Ohkubo F, Masamizu Y, Ohkura M, Nakai J, Okada T, *Matsuzaki M.
Nat. Commun. 2014; 24: 5551.
Rational design of a novel high-affinity, ultrafast, red calcium indicator R-CaMP2. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, *Nakai J, *Kitamura K, *Bito H.
Nat. Methods 2015; 12: 64-70.
RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Ogino K, Low SE, Yamada K, Saint-Amant L, Zhou W, Muto A, Asakawa K, Nakai J, Kawakami K, Kuwada JY, *Hirata H.
Proc. Natl. Acad. Sci. USA 2015; 112: 2859-64.
Aging impairs protein synthesis-dependent long-term memory in Drosophila. Tonoki A. and *Davis RL.
J Neurosci. 2015; 35(3):1173-80.
Caspase inhibition of select olfactory neurons rejuvenates innate attraction behavior in aged Drosophila. Chihara T., Kitabayashi A., Morimoto M., Takeuchi K., Masuyama K.,Tonoki A., Davis RL.,Wang JW., *Miura M.
PLoS Genet. 2014; 10(6): e1004437.
Rapid induction of granule cell elimination in the olfactory bulb by noxious stimulation in mice. Komano-Inoue S, Murata K, Mori K, *Yamaguchi, M.
Neurosci Lett. 2015;598:6-11.
Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb. Komano-Inoue S, Manabe H, Ota M, Kusumoto-Yoshida I, Yokoyama TK, Mori K, *Yamaguchi, M.
Eur J Neurosci. 2014;40(5):2724-33.
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, *Imayoshi I.
J Neurosci. 2014;34(17):5788-99.
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, *Nakai J, *Kitamura K, *Bito H.
Nature Methods. 2015;12(1):64-70.
Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory. Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, *Bito H.
Neuron. 2014; 84(1):92-106.
An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes). Yokoi S, Okuyama T, Kamei Y, Naruse K, Taniguchi Y, Ansai S, Kinoshita M, Young LJ, Takemori N, Kubo T, *Takeuchi H.
PLOS Genetics 11, e1005009 (2015)
野村 洋
Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. Nakayama D, Iwata H, Teshirogi C, Ikegaya Y, Matsuki N, *Nomura H.
J Neurosci. 2015;35(2):819-30.
Frontal association cortex is engaged in stimulus integration during associative learning. Nakayama D, Baraki Z, Onoue K, Ikegaya Y, Matsuki N, *Nomura H.
Curr Biol. 2015;25(1):117-23.
Synaptic plasticity associated with a memory engram in the basolateral amygdala. Nonaka A, Toyoda T, Miura Y, Hitora-Imamura N, Naka M, Eguchi M, Yamaguchi S, Ikegaya Y, Matsuki N, *Nomura H.
J Neurosci. 2014;34(28):9305-9.
Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry. Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, *Hibi M.
Dev Biol. 2015;397(1):1-17.
Sox5 functions as a fate switch in medaka pigment cell development. Nagao Y, Suzuki T, Shimizu A, Kimura T, Seki R, Adachi T, Inoue C, Omae Y, Kamei Y, Hara I, Taniguchi Y, Naruse K, Wakamatsu Y, Kelsh RN, Hibi M, *Hashimoto M.
PLoS Genet. 2014;10(4):e1004246.
Spike-coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements. *Yamaguchi K, Sakurai Y.
Cerebellum. 2014;13(5):651-8.
Brain-machine interfaces can accelerate clarification of the principal mysteries and real plasticity of the brain. *Sakurai Y.
Front Syst Neurosci. 2014;8:104.
Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface. *Sakurai Y, Song K, Tachibana S, Takahashi S.
Front Syst Neurosci. 2014;8:11.
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M.
Neuron. 2014;84(4):753-63.
Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger. *Hirano Y, Saitoe M.
Commun Integr Biol. 2013;6(5):e25152.
Fasting launches CRTC to facilitate long-term memory formation in Drosophila. *Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J, *Saitoe M.
Science. 2013:339:443-6.
八木 健
Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-a cluster. Kaneko R, Abe M, Hirabayashi T, Uchimura A, Sakimura K, Yanagawa Y, *Yagi T.
Sci Rep. 2014;4:6263.
Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, *Yagi T.
Neuron 2014;82(1):94-108.
Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamete receptor phosphorylation. Hosokawa T, Mitsushima D, Kaneko R, *Hayashi Y.
Neuron, 85(1): 60-67, 2014.
Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus. Takase K, Sakimoto Y, Kimura F, *Mitsushima D.
Scientific Reports 4, 3738 doi:10.1038/ srep03738, 2014.
Curtailing effect of awakening on visual responses of cortical neurons by cholinergic activation of inhibitory circuits.Kimura R, Safari MS, Mirnajafi-Zadeh J, Kimura R, Ebina T, Yanagawa Y, *Sohya K, *Tsumoto T.
J Neurosci. 2014;34(30):10122-33.
Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum. Yamaguchi S, Aoki N, Kitajima T, Okamura Y, *Homma KJ.
Commun Integrative Biol. 2014;7(5) :1-4.
Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2. Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, *Okamura Y, Homma KJ.
J Cell Physiol. 2014;229:422-433.
The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice. Sato, M., Ito, M., Nagase, M., Sugimura, Y.K., Takahashi, Y., *Watabe, A.M., Kato, F.
Mol. Brain (2015) 8:22, 1-15
Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory. Ohkawa, N., Saitoh, Y., Suzuki, A., Tsujimura, S., Murayama, E., Kosugi, S., Nishizono, H., Matsuo, M., Takahashi, Y., Nagase, M., Sugimura, Y.K., Watabe, A.M., Kato, F., Inokuchi, K.
Cell Rep. (2015) 11, 261-269.
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission. Nagase, M., Takahashi, Y., Watabe, A.M., Kubo, Y., and Kato, F.
J Neurosci . (2014) 34(7): 2605-2617.
Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties. Watanabe T, Hoshida T, Sakyo J, Kishi M, Tanabe S, Matsuura J, Akiyama J, Nakata M, Tanabe Y, Suzuki A, Watanabe S, *Furuta T.
Org. Biomol. Chem. 2014, 12, 5089-5093.
Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans. Ohta A, Ujisawa T, Sonoda S, *Kuhara A.
Nat Commun. 2014;5:4412. doi: 10.1038/ncomms5412.
Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, *Boyden ES.
Nat Neurosci. 2014;17(8):1123-9.
Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important. Takao K, Hagihara H, *Miyakawa T.
Proc Natl Acad Sci U S A. 2015;112(4):E347-8.
Genomic responses in mouse models greatly mimic human inflammatory diseases. Takao K, *Miyakawa T.
Proc Natl Acad Sci U S A. 2015;112(4):1167-72. Erratum in: Proc Natl Acad Sci U S A. 2015;112(10):E1163-7.
A top-down cortical circuit for accurate sensory perception. Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, *Murayama M.
Neuron, published online, 2015.
Generation and Imaging of Transgenic Mice that Express G-CaMP7 under a Tetracycline Response Element. *Sato M, Kawano M, Ohkura M, Gengyo-Ando K, Nakai J, Hayashi Y.
PLoS One. 2015;10(5):e0125354.
Yanai S, Semba Y, and Endo S. The effect of diazepam on mouse PTSD-like behaviors induced by the 2011 Tohoku earthquake.
Behav Sci Res 53, 27-36, 2014.
Deep cerebellar nuclei play an important role in two-tone discrimination on delay eyeblink conditioning in C57BL/6 mice. Sakamoto T, Endo S.
PLoS One. 2013;8(3):e59880.