文部科学省
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科研費
公募研究募集

本学術領域研究の研究の成果を論文発表される際には、以下の要領で必ず謝辞 をつけて頂きますようお願い致します。
(本領域の英語略称名は Memory dynamism です。)

This work was supported by the Grant-in-Aid for Scientific Research on Innovative Areas "Memory dynamism" (8桁の各自の課題番号) from the Ministry of Education, Culture, Sports, Science and Technology

 

平成28年度


Overlapping memory trace indispensable for linking, but not recalling, individual memories.

富山大学大学院・医学薬学研究部(医学)井ノ口 馨 (平成29年1月27日発表)

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

京都大学・メディカルイノベーションセンター 平野恭敬 (平成28年11月14日発表)

Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.

理化学研究所・脳科学総合研究センター 吉原 良浩 (平成28年5月30日発表)

 

平成27年度


Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.

筑波大学・国際統合睡眠医科学研究機構 林悠 (平成27年10月22日発表)

Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection

東北大学・生命科学研究科 細川貴之 (平成28年3月9日発表)

 

平成26年度


Glial dysfunction causes age-related memory impairment in Drosophila.

東京都医学総合研究所・運動感覚システム研究分野  齊藤実 (平成26年11月19日発表)

Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory.

東京大学・大学院医学系研究科  尾藤晴彦 (平成26年10月1日発表)

Light and pheromone-sensing neuron regulates cold habituation through insulin signaling in C. elegans

甲南大学・理工学部/ 統合ニューロバイオロジー研究所 久原篤 (平成26年7月22日発表)

線虫インスリン受容体のシナプス部位への輸送が記憶に必須である

東京大学・大学院理学系研究科 飯野雄一 (平成26年7月18日発表)

Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling

理化学研究所・脳科学総合研究センター 吉原良浩 (平成26年4月9日発表)

 

太字下線:研究代表者、下線:研究分担者または連携研究者、*印:corresponding author

計画研究

井ノ口馨
Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory. Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, *Inokuchi K.
Cell Rep. 2015;11(2):261-9.
Does autophagy work in synaptic plasticity and memory? Shehata M, *Inokuchi K.
Rev Neurosci. 2014;25(4):543-57.
Role of adult neurogenesis in hippocampal-cortical memory consolidation. Kitamura T, *Inokuchi K.
Mol Brain. 2014;7:13.
松尾直毅
Irreplaceability of neuronal ensembles after memory allocation. *Matsuo N.
Cell Reports 2015: S2211-1247(15)00321-6.
久恒辰博
Research and development of Ultra High Field MRI. *Hisatsune T.
Magnetics Jpn. 2014. 9: 180-186.
β-Alanyl-L-Histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer’s Disease. Herculano BA, Tamura M, Ohba A, Shimatani M, Kutsuna N, *Hisatsune T.
Journal of Alzheimer’s Disease 2013. 33, 983–997.
Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cell after focal cerebral ischemia in mice. Nochi R, Kaneko J, Okada N, Terazono Y, Matani A, *Hisatsune T.
Journal of Neuroscience Research 2013. 91, 1429-1439.
吉原良浩
Contactin-4 Mediates Axon-Target Specificity and Functional Development of the Accessory Optic System. Osterhout JA, Stafford BK, Nguyen PL, Yoshihara Y, *Huberman AD.
Neuron. 2015;86(4):985-999.
The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Amo R, Fredes F, Kinoshita M, Aoki R, Aizawa H, Agetsuma M, Aoki T, Shiraki T, Kakinuma H, Matsuda M, Yamazaki M, Takahoko M, Tsuboi T, Higashijima S, Miyasaka N, Koide T, Yabuki Y, Yoshihara Y, Fukai T, *Okamoto H.
Neuron. 2014;84(5):1034-48.
Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling. * Miyasaka N, Arganda-Carreras I, Wakisaka N, Masuda M, Sümbül U, Seung HS, *Yoshihara Y.
Nat Commun. 2014;5:3639.
Goofy coordinates the acuity of olfactory signaling. Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, *Yoshihara Y.
J Neurosci. 2013;33(32):12987-96, 12996a.
齊藤 実
Long-term memory formation in Drosophila requires training-dependent glial transcription. Matsuno M, Horiuchi J, Yuasa Y, Ofusa K, Miyashita T, Masuda T, *Saitoe M.
J Neurosci. 2015;35(14):5557-65.
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi, Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M. (2014).
Neuron. 2014;84(4):753-63.
Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction. Kamimura K, Ueno K, Nakagawa J, Hamada R, Saitoe M, *Maeda N.
J Cell Biol. 2013;200(2):219-33.
Fasting Launches CRTC to Facilitate Long-term Memory Formation in Drosophila. *Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J, *Saitoe M.
Science 2013;339(6118):443-6.
上川内あづさ
Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston’s organ of the fruit fly. *Matsuo E, Yamada D, Ishikawa Y, Asai T, Ishimoto H, *Kamikouchi A.
Frontiers in Physiology 2014;5:179.
Selectivity and plasticity in a sound-evoked male-male interaction in Drosophila. Yoon J, Matsuo E, Yamada D, Mizuno H, Morimoto T, Miyakawa H, Kinoshita S, Ishimoto H, *Kamikouchi A.
PLOS ONE 2013. 8, e74289.
多羽田哲也
Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila. Hiroi M, Ohkura M, Nakai J, Masuda N, Hashimoto K, Inoue K, Fiala A,*Tabata T.
Genes Cells. 2013;18(12):1070-81.
The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway. Abe T, Yamazaki D, Murakami S, Hiroi M, Nitta Y, Maeyama Y, *Tabata T.
Development. 2014;141(24):4716-28.
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M.
Neuron. 2014;84(4):753-63.
石原 健
Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans. Dillon J, Franks CJ, Murray C, Edwards RJ, Calahorro F, Ishihara T, Katsura I, Holden-Dye L, *O'Connor V.
J Biol Chem. 2015. pii: jbc.M114.606608. [Epub ahead of print]
Automated detection and tracking of many cells by using 4D live-cell imaging data. Tokunaga T, Hirose O, Kawaguchi S, Toyoshima Y, Teramoto T, Ikebata H, Kuge S, Ishihara T, Iino Y, *Yoshida R.
Bioinformatics. 2014;30(12):i43-51.
飯野雄一
Kato HE, Inoue K, Abe-Yoshizumi R, Kato Y, Ono H, Konno M, Hososhima S, Ishizuka T, Hoque MR, Kunitomo H, Ito J, Yoshizawa S, Yamashita K, Takemoto M, Nishizawa T, Taniguchi R, Kogure K, Maturana AD, Iino Y, Yawo H, Ishitani R, Kandori H, *Nureki O. Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump.
Nature. 2015;521(7550):48-53.
Regulation of experience-dependent bidirectional chemotaxis by a neural circuit switch in Caenorhabditis elegans. Satoh Y, Sato H, Kunitomo H, Fei X, Hashimoto K, *Iino Y.
J Neurosci. 2014;34(47):15631-7.
Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans. Ohno H, Kato S, Naito Y, Kunitomo H, *Tomioka M, *Iino Y.
Science. 2014;345(6194):313-7.
Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans. Kunitomo H, Sato H, Iwata R, Satoh Y, Ohno H, Yamada K, *Iino Y.
Nat Commun. 2013;4:2210.
 

公募研究

坂口昌徳
Inhibiting the activity of CA1 hippocampal neurons prevents the recall of contextual fear memory in inducible ArchT transgenic mice. *Sakaguchi M, Kim K, Yu LMY, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ, *Hayashi Y,
PloS One, 2015, in press
Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, *Frankland PW.
J Neurosci. 2014;34(47):15793-803.
林 悠
Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. Arakawa H, Suzuki A, Zhao S, Tsytsarev V, Lo FS, Hayashi Y, Itohara S, Iwasato T, *Erzurumlu RS.
J Neurosci. 2014;34(36):12001-14.
中井淳一
Reward-timing-dependent bidirectional modu- lation of cortical microcircuits during optical single neuron operant conditioning. Hira R, Ohkubo F, Masamizu Y, Ohkura M, Nakai J, Okada T, *Matsuzaki M.
Nat. Commun. 2014; 24: 5551.
Rational design of a novel high-affinity, ultrafast, red calcium indicator R-CaMP2. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, *Nakai J, *Kitamura K, *Bito H.
Nat. Methods 2015; 12: 64-70.
RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Ogino K, Low SE, Yamada K, Saint-Amant L, Zhou W, Muto A, Asakawa K, Nakai J, Kawakami K, Kuwada JY, *Hirata H.
Proc. Natl. Acad. Sci. USA 2015; 112: 2859-64.
殿城亜矢子
Aging impairs protein synthesis-dependent long-term memory in Drosophila. Tonoki A. and *Davis RL.
J Neurosci. 2015; 35(3):1173-80.
Caspase inhibition of select olfactory neurons rejuvenates innate attraction behavior in aged Drosophila. Chihara T., Kitabayashi A., Morimoto M., Takeuchi K., Masuyama K.,Tonoki A., Davis RL.,Wang JW., *Miura M.
PLoS Genet. 2014; 10(6): e1004437.
山口正洋
Rapid induction of granule cell elimination in the olfactory bulb by noxious stimulation in mice. Komano-Inoue S, Murata K, Mori K, *Yamaguchi, M.
Neurosci Lett. 2015;598:6-11.
Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb. Komano-Inoue S, Manabe H, Ota M, Kusumoto-Yoshida I, Yokoyama TK, Mori K, *Yamaguchi, M.
Eur J Neurosci. 2014;40(5):2724-33.
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, *Imayoshi I.
J Neurosci. 2014;34(17):5788-99.
尾藤晴彦
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, *Nakai J, *Kitamura K, *Bito H.
Nature Methods. 2015;12(1):64-70.
Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory. Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, *Bito H.
Neuron. 2014; 84(1):92-106.
竹内秀明
An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes). Yokoi S, Okuyama T, Kamei Y, Naruse K, Taniguchi Y, Ansai S, Kinoshita M, Young LJ, Takemori N, Kubo T, *Takeuchi H.
PLOS Genetics 11, e1005009 (2015)
野村 洋
Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. Nakayama D, Iwata H, Teshirogi C, Ikegaya Y, Matsuki N, *Nomura H.
J Neurosci. 2015;35(2):819-30.
Frontal association cortex is engaged in stimulus integration during associative learning. Nakayama D, Baraki Z, Onoue K, Ikegaya Y, Matsuki N, *Nomura H.
Curr Biol. 2015;25(1):117-23.
Synaptic plasticity associated with a memory engram in the basolateral amygdala. Nonaka A, Toyoda T, Miura Y, Hitora-Imamura N, Naka M, Eguchi M, Yamaguchi S, Ikegaya Y, Matsuki N, *Nomura H.
J Neurosci. 2014;34(28):9305-9.
日比正彦
Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry. Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, *Hibi M.
Dev Biol. 2015;397(1):1-17.
Sox5 functions as a fate switch in medaka pigment cell development. Nagao Y, Suzuki T, Shimizu A, Kimura T, Seki R, Adachi T, Inoue C, Omae Y, Kamei Y, Hara I, Taniguchi Y, Naruse K, Wakamatsu Y, Kelsh RN, Hibi M, *Hashimoto M.
PLoS Genet. 2014;10(4):e1004246.
櫻井芳雄
Spike-coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements. *Yamaguchi K, Sakurai Y.
Cerebellum. 2014;13(5):651-8.
Brain-machine interfaces can accelerate clarification of the principal mysteries and real plasticity of the brain. *Sakurai Y.
Front Syst Neurosci. 2014;8:104.
Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface. *Sakurai Y, Song K, Tachibana S, Takahashi S.
Front Syst Neurosci. 2014;8:11.
平野恭敬
Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, *Saitoe M.
Neuron. 2014;84(4):753-63.
Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger. *Hirano Y, Saitoe M.
Commun Integr Biol. 2013;6(5):e25152.
Fasting launches CRTC to facilitate long-term memory formation in Drosophila. *Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J, *Saitoe M.
Science. 2013:339:443-6.
八木 健
Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-a cluster. Kaneko R, Abe M, Hirabayashi T, Uchimura A, Sakimura K, Yanagawa Y, *Yagi T.
Sci Rep. 2014;4:6263.
Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, *Yagi T.
Neuron 2014;82(1):94-108.
美津島大
Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamete receptor phosphorylation. Hosokawa T, Mitsushima D, Kaneko R, *Hayashi Y.
Neuron, 85(1): 60-67, 2014.
Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus. Takase K, Sakimoto Y, Kimura F, *Mitsushima D.
Scientific Reports 4, 3738 doi:10.1038/ srep03738, 2014.
木村梨絵
Curtailing effect of awakening on visual responses of cortical neurons by cholinergic activation of inhibitory circuits.Kimura R, Safari MS, Mirnajafi-Zadeh J, Kimura R, Ebina T, Yanagawa Y, *Sohya K, *Tsumoto T.
J Neurosci. 2014;34(30):10122-33.
本間光一
Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum. Yamaguchi S, Aoki N, Kitajima T, Okamura Y, *Homma KJ.
Commun Integrative Biol. 2014;7(5) :1-4.
Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2. Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, *Okamura Y, Homma KJ.
J Cell Physiol. 2014;229:422-433.
渡部文子
The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice. Sato, M., Ito, M., Nagase, M., Sugimura, Y.K., Takahashi, Y., *Watabe, A.M., Kato, F.
Mol. Brain (2015) 8:22, 1-15
Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory. Ohkawa, N., Saitoh, Y., Suzuki, A., Tsujimura, S., Murayama, E., Kosugi, S., Nishizono, H., Matsuo, M., Takahashi, Y., Nagase, M., Sugimura, Y.K., Watabe, A.M., Kato, F., Inokuchi, K.
Cell Rep. (2015) 11, 261-269.
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission. Nagase, M., Takahashi, Y., Watabe, A.M., Kubo, Y., and Kato, F.
J Neurosci . (2014) 34(7): 2605-2617.
古田寿昭
Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties. Watanabe T, Hoshida T, Sakyo J, Kishi M, Tanabe S, Matsuura J, Akiyama J, Nakata M, Tanabe Y, Suzuki A, Watanabe S, *Furuta T.
Org. Biomol. Chem. 2014, 12, 5089-5093.
久原篤
Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans. Ohta A, Ujisawa T, Sonoda S, *Kuhara A.
Nat Commun. 2014;5:4412. doi: 10.1038/ncomms5412.
小川正晃
Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, *Boyden ES.
Nat Neurosci. 2014;17(8):1123-9.
高雄啓三
Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important. Takao K, Hagihara H, *Miyakawa T.
Proc Natl Acad Sci U S A. 2015;112(4):E347-8.
Genomic responses in mouse models greatly mimic human inflammatory diseases. Takao K, *Miyakawa T.
Proc Natl Acad Sci U S A. 2015;112(4):1167-72. Erratum in: Proc Natl Acad Sci U S A. 2015;112(10):E1163-7.
佐藤正晃
A top-down cortical circuit for accurate sensory perception. Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, *Murayama M.
Neuron, published online, 2015.
Generation and Imaging of Transgenic Mice that Express G-CaMP7 under a Tetracycline Response Element. *Sato M, Kawano M, Ohkura M, Gengyo-Ando K, Nakai J, Hayashi Y.
PLoS One. 2015;10(5):e0125354.
遠藤昌吾
Yanai S, Semba Y, and Endo S. The effect of diazepam on mouse PTSD-like behaviors induced by the 2011 Tohoku earthquake.
Behav Sci Res 53, 27-36, 2014.
Deep cerebellar nuclei play an important role in two-tone discrimination on delay eyeblink conditioning in C57BL/6 mice. Sakamoto T, Endo S.
PLoS One. 2013;8(3):e59880.
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